منابع مشابه
Tamoxifen therapy and carcinogenic risk.
It is quite remarkable that tamoxifen, a drug that is so effective in the treatment of breast cancer, should have so low a toxicity profile. Since 1971, tamoxifen has been used to treat many millions of patients for periods sometimes in excess of 10 years, in doses sometimes eightfold higher than the usual dose; yet the incidence of serious toxic effects from tamoxifen has been almost negligibl...
متن کاملStroke risk and tamoxifen therapy for breast cancer.
BACKGROUND Tamoxifen, which is used widely to treat, and increasingly to prevent, breast cancer, has been associated with increased risk of stroke. We assessed the impact of tamoxifen treatment for breast cancer on the risk of stroke, considering dose, duration, and recency of use of tamoxifen and known stroke risk factors. METHODS We conducted a nested case-control study of stroke after brea...
متن کاملTamoxifen therapy for breast cancer and endometrial cancer risk.
BACKGROUND Tamoxifen is effective in treating breast cancer, reduces breast cancer incidence among high-risk women, and is associated with increased endometrial cancer risk. This study was designed to examine the possible modifying effects of endometrial cancer risk factors on the tamoxifen-endometrial cancer association. METHODS We conducted a case-control study of endometrial cancer (324 ca...
متن کاملCarcinogenic and Non-Carcinogenic Risk Assessment of Some Heavy Metals Due to Consumption of Raisin Produced in Malayer City
Carcinogenic and Non-Carcinogenic Risk Assessment of Some Heavy Metals Due to Consumption of Raisin Produced in Malayer City Eisa solgi1*, Tarokh khodadadi2 1Associate Professor, Department of Environment, Faculty of Natural Resources and Environment, Malayer University 2Ph.D. Student of Environmental Pollution, Faculty of Natural Resources and Environment, Malayer University Abstract In...
متن کاملTamoxifen Therapy and CYP2D6 Genotype
The CYP2D6 enzyme metabolizes a quarter of all prescribed drugs, and is one of the main enzymes responsible for converting tamoxifen into its active metabolites. Individuals who carry two nonfunctioning copies of CYP2D6 are known as poor metabolizers. Individuals who carry one or two decreased activity alleles are referred to as intermediate metabolizers. Importantly, there are also heterozygou...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1995
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/87.18.1343